Results
| PMID | 14506929 |
| Gene Name | CXCL10 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 120 |
| Population details | 120 patients undergoing laparoscopy for pain and/or infertility |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | IP-10, IP-10 receptor, CXCR3 |
| Other associated phenotypes |
Advanced endometriosis, Infertility |
|
Am J Reprod Immunol. 2003 Jul;50(1):60-5. Yoshino, Osamu| Osuga, Yutaka| Koga, Kaori| Hirota, Yasushi| Tsutsumi, Osamu| Yano, Tetsu| Morita, Yutaka| Momoeda, Mikio| Fujiwara, Toshihiro| Kugu, Koji| Taketani, Yuji Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan. PROBLEM: To assess whether interferon-gamma-induced protein-10 (IP-10), a chemokine that has antiangiogenic activities, may be involved in the pathogenesis of endometriosis. METHOD OF STUDY: A total of 120 patients undergoing laparoscopy for pain and/or infertility were recruited, and peritoneal fluid (PF) and bone marrow derived cells in PF were collected. Concentrations of IP-10 in PF were measured with a specific enzyme-linked immunosorbent assay. Expression of IP-10 and IP-10 receptor, CXCR3, in bone marrow derived cells in PF, peritoneum and endometriotic cells was analyzed by reverse transcription-polymerase chain reaction. RESULTS: All of the PF samples examined contained detectable concentrations of IP-10. In women with advanced stages of endometriosis, IP-10 concentrations in PF were significantly lower than those of women in early stages (P = 0.02). The IP-10 concentrations in women with advanced endometriosis also appeared to be lower than those without endometriosis although the difference was statistically marginal (P = 0.06). The expression of both IP-10 and CXCR3 was clearly detected in the bone marrow derived cells in PF, peritoneum and endometriotic stromal cells. CONCLUSIONS: Decreased concentrations of IP-10 in PF from women with advanced stages of endometriosis may imply that the peritoneal environment of these women is permissive to the development of the disease by enhancing angiogenesis and/or modulating inflammatory/immunological responses. Mesh Terms: Adult| Ascitic Fluid/*chemistry| Chemokine CXCL10| Chemokines, CXC/genetics/*metabolism| Endometriosis/metabolism/*pathology| Enzyme-Linked Immunosorbent Assay| Female| Humans| Peritoneal Cavity/pathology| RNA, Messenger/metabolism| Receptors, C |
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